姓名/職稱:李磊/副教授
性 別:男
職 務(wù):基礎(chǔ)獸醫(yī)學(xué)教研室主任
畢業(yè)院校:內(nèi)蒙古農(nóng)業(yè)大學(xué)
最高學(xué)位:博士
辦公電話:18365075200
電子郵箱:lil@ahstu.edu.cn
研究方向:獸醫(yī)藥理學(xué)與毒理學(xué)、中藥藥理學(xué)
個(gè)人簡(jiǎn)介:
2008年6月畢業(yè)于西南大學(xué)藥學(xué)專業(yè),獲學(xué)士學(xué)位;2014年6月畢業(yè)于內(nèi)蒙古農(nóng)業(yè)大學(xué)基礎(chǔ)獸醫(yī)學(xué)專業(yè)獸醫(yī)藥理學(xué)與毒理學(xué)方向,獲博士學(xué)位;2016年7月至2019年6月赴上海中醫(yī)藥大學(xué)中藥研究所開(kāi)展博士后研究;2019年9月至2020年8月赴英國(guó)亞伯大學(xué)進(jìn)行訪學(xué)研究?,F(xiàn)為中國(guó)畜牧獸醫(yī)學(xué)會(huì)獸醫(yī)藥理與毒理學(xué)分會(huì)理事,安徽省畜牧獸醫(yī)學(xué)會(huì)會(huì)員、安徽省動(dòng)物保健品協(xié)會(huì)會(huì)員、中國(guó)生物物理學(xué)會(huì)生物微量元素分會(huì)會(huì)員,安徽科技學(xué)院校級(jí)教壇新秀。個(gè)人研究興趣:抗炎免疫藥理、中藥活性成分對(duì)動(dòng)物肝臟的保護(hù)作用。
主持或參與項(xiàng)目:
1、主持國(guó)家自然科學(xué)基金項(xiàng)目:?;蛆Z去氧膽酸激活Nrf2負(fù)調(diào)控NLRP3炎癥體抗炎作用機(jī)制的研究,項(xiàng)目編號(hào):31802242,(2019.01-2021.12);
2、主持安徽省高校自然科學(xué)研究重點(diǎn)項(xiàng)目:天然產(chǎn)物穿心蓮內(nèi)酯調(diào)控MAPK/Nrf2信號(hào)通路干預(yù)NASH的研究,項(xiàng)目編號(hào):KJ2017A503,(2017.01-2018.12);
3、主持安徽省教育廳高校優(yōu)秀拔尖人才培育資助項(xiàng)目,高校優(yōu)秀青年骨干人才國(guó)外訪學(xué)研修項(xiàng)目,項(xiàng)目編號(hào):gxgwfx2019047,(2019.05-2021.04);
4、主持安徽省高等學(xué)校質(zhì)量工程項(xiàng)目,基層教研室示范項(xiàng)目,基礎(chǔ)獸醫(yī)學(xué)教研室,項(xiàng)目編號(hào):2018jyssf065,(2019.01-2020.12);
5、主持安徽科技學(xué)院引進(jìn)人才項(xiàng)目:牛磺鵝去氧膽酸對(duì)佐劑性關(guān)節(jié)炎模型大鼠成纖維樣滑膜細(xì)胞JNK-AP-1信號(hào)轉(zhuǎn)導(dǎo)通路及其凋亡的影響,項(xiàng)目編號(hào):ZRC2014447,(2015.01-2017.12)
6、參加國(guó)家自然科學(xué)基金項(xiàng)目:TCDCA對(duì)糖皮質(zhì)激素受體介導(dǎo)基因組學(xué)信號(hào)轉(zhuǎn)導(dǎo)通路的影響,項(xiàng)目編號(hào):31160518,(2012.01-2014.12);
7、參加國(guó)家自然科學(xué)基金項(xiàng)目:牛磺鵝去氧膽酸對(duì)大鼠肺泡巨噬細(xì)胞中TGR5受體介導(dǎo)的信號(hào)通路的影響,項(xiàng)目編號(hào):31272605,(2013.01-2016.12);
8、參加國(guó)家自然科學(xué)基金項(xiàng)目:?;蛆Z去氧膽酸對(duì)糖皮質(zhì)激素受體介導(dǎo)的非基因組學(xué)信號(hào)通路的影響,項(xiàng)目編號(hào):31402248,(2015.01-2017.12)。
主要研究成果及發(fā)表論文:
1.Lei Li, Shenghe Li, Jinpeng Jiang, Chang Liu, Lili Ji. Investigating pharmacological mechanisms of andrographolide on non-alcoholic steatohepatitis (NASH): A bioinformatics approach of network pharmacology[J]. Chinese Herbal Medicines,2021, 13(3): 342-350.
2. Chang Liu, Yaohui Zhu, Zhenxiang Lu, Weina Guo, Bayaer Tumen, Yalan He, Chao Chen, Shanshan Hu, Kangzhi Xu, Yan Wang,Lei Li*(通信作者), Shenghe Li*. Cadmium Induces Acute Liver Injury by Inhibiting Nrf2 and the Role of NF-κB, NLRP3, and MAPKs Signaling Pathway[J]. Int J Environ Res Public Health, 2020, 17:138.
3.Lei Li, Chang Liu*, Wei Mao, Bayaer Tumen, Peifeng Li. Taurochenodeoxycholic Acid Inhibited AP-1 Activation via Stimulating Glucocorticoid Receptor[J]. Molecules,2019,24: 4513.
4.Lei Li, Wenxiang Huang, Shoukai Wang, Kecheng Sun, Wenxue Zhang, Yanmei Ding, Le Zhang, Bayaer Tumen, Lili Ji*, Chang Liu*. Astragaloside IV Attenuates Acetaminophen- Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway[J]. Molecules 2018, 23(8):2032.
5.Lei Li, Xiaojiao Hou, Rongfang Xu, Chang Liu*, Menbayaer Tu*, Research review on the pharmacological effects of Astragaloside IV[J]. Fundamental Clinical Pharmacology, 2017, 31(1): 17-36.
6.Lei Li, Chang Liu, Mingqiang Liu, Linkai Shi, Qian Liu, Hong Guan*, Peifeng Li*, Taurochenodeoxycholic acid induces apoptosis of fibroblast-like synoviocytes[J]. European Journal of Pharmacology, 2013, 706(1-3): 36-40.
7. Caiyun Wang#,Lei Li# (共同第一作者), Hong Guan, Saiyinna Tong, Mingqiang Liu, Chang Liu, Ziying Zhang, Chenguang Du, Peifeng Li*, Effects of taurocholic acid on immunoregulation in mice[J]. International Immunopharmacology, 2013, 15(2): 217-222.
8. Mingqiang Liu, Wei Mao, Hong Guan,Lei Li, Bo Wei, Peifeng Li*, Effects of taurochenodeoxycholic acid on adjuvant arthritis in rats[J]. International Immunopharmacology, 2011, 11(12): 2150-2158.
9.李磊,趙花金,伍子燾,李升和,姜錦鵬,劉暢.決明子抗氧化作用機(jī)制的網(wǎng)絡(luò)藥理學(xué)分析[J].浙江農(nóng)業(yè)學(xué)報(bào), 2020,32(10): 1855-1865.
10.李磊,圖門(mén)巴雅爾,李培鋒,劉暢,李升和,寧康健,姜錦鵬.?;蛆Z去氧膽酸抗炎作用機(jī)制的網(wǎng)絡(luò)藥理學(xué)研究[J].藥學(xué)學(xué)報(bào), 2018,53(12): 2064-2075.